Research Paper Volume 12, Issue 20 pp 20184—20197

Interleukin-6 knockout reverses macrophage differentiation imbalance and alleviates cardiac dysfunction in aging mice

Figure 3. Effects of IL-6 KO on cardiac remodeling and aging-related protein levels. (AC) Body weights (BWs), heart weights (HWs), and HW/BW ratios in the four groups. (D) MC CSA and cardiac fibrosis area in each group. (E) Lipofuscin density in each group. (F) p16, p19, p21, p53, and Sirt1 mRNA expression levels were analyzed by RT-PCR. (G) Cardiac p53 protein expression was detected by immunofluorescence staining. N=5-8 in each group. * p<0.05 vs. the young WT group; # p<0.05 vs. the aging WT group.