Research Paper Volume 12, Issue 20 pp 20184—20197

Interleukin-6 knockout reverses macrophage differentiation imbalance and alleviates cardiac dysfunction in aging mice

Figure 4. Effect of IL-6 KO on cardiac Mø differentiation. (A) STAT1 and p65 phosphorylation was detected by Western blotting. (B) Cardiac iNOS and Arg-1 levels were measured by immunofluorescence staining. (C) mRNA expression of Mø1- and Mø2-related markers in each group. N=5-8 in each group. * p<0.05 vs. the young WT group; # p<0.05 vs. the aging WT group.