Research Paper Volume 12, Issue 20 pp 20184—20197

Interleukin-6 knockout reverses macrophage differentiation imbalance and alleviates cardiac dysfunction in aging mice

Figure 6. Effects of IL-6 KO on Mø differentiation and MC apoptosis in vitro. (A). The levels of p65 phosphorylation in DOX-treated WT Møs and IL-6 KO Møs were measured. (B, C). The mRNA expression of Mø1- and Mø2-related markers was measured in DOX-treated Møs. (D). The effects of DOX-induced Mø differentiation on MC apoptosis and MC aging were determined by RT-PCR. N=5 in each group. * p<0.05 vs. the young WT group; # p<0.05 vs. the aging WT group.