Research Paper Volume 12, Issue 21 pp 21129—21146

LINC00452 promotes ovarian carcinogenesis through increasing ROCK1 by sponging miR-501-3p and suppressing ubiquitin-mediated degradation

Figure 5. LINC00452 activates the downstream signals of ROCK1 protein. LINC00452 was knocked down alone or in combination with miR-501-3p knockdown. The protein levels of p-LIMK1, LIMK1, p-cofilin and cofilin were assessed in CaOV3 using western blot assay. * p < 0.05, ** p < 0.01; *** p < 0.001 versus control group.