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Research Paper Volume 12, Issue 20 pp 20212—20225

LINC00265 targets miR-382-5p to regulate SAT1, VAV3 and angiogenesis in osteosarcoma


Figure 7. LINC00265 regulated osteosarcoma cell metastasis and tube formation by targeted regulation of miR-382-5p/SAT1 and miR-382-5p/VAV3. (A, B) The expression level of LINC00265 and miR-382-5p in each group. (C–F) The expression level of SAT1 and VAV3 mRNA and protein in each group. (G, H) CCK-8 and colony formation assays were used to detect cell viability and proliferation. (I, J) Wound healing and Transwell assays were applied to detect cell migration and invasive ability. (K) The tube production capacity of the cells was detected using the tube formation assay. *P < 0.05 vs. sh-NC+inhibitor-NC group; #P < 0.05 vs. sh-LINC00265+inhibitor-NC group.