Research Paper Volume 12, Issue 20 pp 20212—20225

LINC00265 targets miR-382-5p to regulate SAT1, VAV3 and angiogenesis in osteosarcoma

Figure 8. LINC00265 regulated osteosarcoma growth by regulating miR-382-5p/SAT1 and miR-382-5p/VAV3. (A, B) Effects of LINC00265 and miR-382-5p on tumour mass and volume. (C, D) Effects of LINC00265 on the expression levels of SAT1 and VAV3 mRNAs by targeting miR-382-5p. (E, F) Effects of LINC00265 on the expression levels of SAT1 and VAV3 by targeting miR-382-5p. (G, H) Immunohistochemistry staining was used to detect the expression of SAT1 and VAV3 proteins in tumour tissues. *P < 0.05 vs. sh-NC+inhibitor-NC group; #P < 0.05 vs. sh-LINC00265+inhibitor-NC group.