Research Paper Volume 12, Issue 20 pp 20235—20253

ARHGEF11 promotes proliferation and epithelial-mesenchymal transition of hepatocellular carcinoma through activation of β-catenin pathway

Figure 1. ARHGEF11 is upregulated in HCC tissues. (A) Representative IHC staining of ARHGEF11 in HCC tissues, scale bar 200 μm. (B) Three representative IHC staining images of ARHGEF11 in HCC and para-tumor tissues (left), scale bar 100 μm. Quantification of ARHGEF11 expression of paired HCC samples (n=107, right). Data are shown as mean ± SD. (C) Representative qRT-PCR results of ARHGEF11 expression of human HCC samples. Data are shown as mean ± SD. (DF) Relative ARHGEF11 mRNA expression in GEO dataset (GSE64041), TCGA dataset and four Oncomine datasets respectively. (G) Relative ARHGEF11 expression in five hepatoma cell lines, as detected by western blot. ***P<0.001.