Research Paper Volume 12, Issue 20 pp 20235—20253

ARHGEF11 promotes proliferation and epithelial-mesenchymal transition of hepatocellular carcinoma through activation of β-catenin pathway

Figure 8. Graphical model displaying the mechanisms of ARHGEF11 in regulating cell cycle and EMT via activating β-catenin. Upregulation of ARHGEF11 promotes β-catenin nuclear translocation from cell membrane. β-catenin activates cyclinD1 transcription, which then leads to cell cycle progression. At the same time, β-catenin enhances ZEB1 transcription, which can inhibit E-cadherin expression, thereby inducing EMT.