Research Paper Volume 12, Issue 20 pp 20254—20267

Development and validation of an immune and stromal prognostic signature in uveal melanoma to guide clinical therapy

Figure 4. Identification of optimal cell signature for overall survival (OS) prediction. (A) The process of building the signature containing four cell types (3 immune cells and 1 stromal cell) and the coefficients calculated using the lasso method: from 500 iterations of lasso-penalized multivariate modeling, four cell types were reported as optimal for survival prediction more than 400 times; (B) The AUC curves of cell type models and Kaplan–Meier survival analysis of four-cell-type model in TCGA. Then the number of cells is four, the value of AUC is the highest (0.802). Kaplan–Meier curves indicated that there is a significant difference between high- and low-risk groups (log-rank P < 0.001).