Research Paper Volume 12, Issue 21 pp 21147—21160

Melatonin exerts immunoregulatory effects by balancing peripheral effector and regulatory T helper cells in myasthenia gravis

Figure 4. Melatonin significantly decreased the proliferation of CD4+ T cells isolated from either MG patients or HCs but did not alter cell viability. (A) CFSE assay of PHA-stimulated proliferation of melatonin- or vehicle-treated CD4+ T cells. (B) Viability of melatonin-stimulated or unstimulated CD4+ T cells (HC, n=10; MG, n=10). The data are presented as the mean ± SD. ** P ≤ 0.01, *** P ≤ 0.001 and ns=no significance.