Research Paper Volume 12, Issue 22 pp 22550—22563

The therapeutic value of XL388 in human glioma cells

Figure 1. XL388 potently inhibits glioma cell survival, proliferation, migration, invasion and cell cycle progression. A172 cells (AH), U251MG cells (“U251”) (IK) and primary human glioma cells (“Pri-1/Pri-2”) (IK) were treated with applied concentrations of XL388 or the vehicle control (“C”, same for all Figures), and cultured for applied time periods, then cellular functions including cell survival (A, B and I), proliferation (CE, and J), migration (F and K), invasion (G) and cell cycle progression (H) were tested by the indicated assays. Results were quantified. Expression of listed proteins was shown (A). Data were presented as mean ± SD (n=5). * p <0.05 vs. “C” cells. Experiments in this figure were repeated three times, and similar results were obtained. Bar= 100 μm (D, F and G).