Online ISSN: 1945-4589
The cover features Figure 2 "Telomere length changes with HBOT“ from Hachmo et al.

Volume 12, Issue 22

30 November, 2020
pp 22350—23421

About the Cover

The cover features Figure 2 "Telomere length changes with HBOT“ from Hachmo et al.


Table of Contents

Editorials

The price of longevity

Nico P. Dantuma, Thorsten Hoppe, Laura K. Herzog,
https://doi.org/10.18632/aging.104215 pp 22350—22351
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Measuring biological age using metabolomics

Oliver Robinson, Chung-Ho E. Lau,
https://doi.org/10.18632/aging.104216 pp 22352—22353
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Family matters in unraveling human longevity

Niels van den Berg,
https://doi.org/10.18632/aging.104218 pp 22354—22355
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Theory Article

Proposing a minimal set of metrics and methods to predict probabilities of amyloidosis disease and onset age in individuals

Richard S. Criddle, Hsien-Jung L. Lin, Isabella James, Ji Sun Park, Lee D. Hansen, John C. Price,
https://doi.org/10.18632/aging.202208 pp 22356—22369
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Letter to the Editor

COVID-19
Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer

Huimin Li, Longxiang Xie, Lin Chen, Lu Zhang, Yali Han, Zhongyi Yan, Xiangqian Guo,
https://doi.org/10.18632/aging.104147 pp 22370—22389
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Research Papers

COVID-19
High incidence of stroke in COVID-19 patients

Jingyu Chen, Yazhou Wu, Zhi Chen, Bin Yi, Lili Zhang, Changlin Yin, Hua Feng,
https://doi.org/10.18632/aging.104092 pp 22390—22398
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COVID-19
Impact of age on duration of viral RNA shedding in patients with COVID-19

Chenliang Zhou, Tianfang Zhang, Haotang Ren, Shanshan Sun, Xia Yu, Jifang Sheng, Yu Shi, Hong Zhao,
https://doi.org/10.18632/aging.104114 pp 22399—22404
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COVID-19
Clinical characteristics of the first known cases of death caused by COVID-19 pneumonia

Fan-Zhen Kong, Yi Wang, Mei-Xia Wang, Qing-Zhang Cheng, Robert Logan, Guan-Hui Wu, Si-Ming Hu,
https://doi.org/10.18632/aging.104171 pp 22405—22412
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COVID-19
Estimating the release of inflammatory factors and use of glucocorticoid therapy for COVID-19 patients with comorbidities

Dan Han, Chunfen Peng, Rui Meng, Jing Yao, Qiong Zhou, Yong Xiao, Hong Ma,
https://doi.org/10.18632/aging.202172 pp 22413—22424
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COVID-19
In search of preventive strategies: novel high-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues

Bo Wang, Anna Kovalchuk, Dongping Li, Rocio Rodriguez-Juarez, Yaroslav Ilnytskyy, Igor Kovalchuk, Olga Kovalchuk,
https://doi.org/10.18632/aging.202225 pp 22425—22444
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Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial

Yafit Hachmo, Amir Hadanny, Ramzia Abu Hamed, Malka Daniel-Kotovsky, Merav Catalogna, Gregory Fishlev, Erez Lang, Nir Polak, Keren Doenyas, Mony Friedman, Yonatan Zemel, Yair Bechor, Shai Efrati,
https://doi.org/10.18632/aging.202188 pp 22445—22456
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Generalized correlation coefficient for genome-wide association analysis of cognitive ability in twins

Afsaneh Mohammadnejad, Marianne Nygaard, Shuxia Li, Dongfeng Zhang, Chunsheng Xu, Weilong Li, Jesper Lund, Lene Christiansen, Jan Baumbach, Kaare Christensen, Jacob v. B. Hjelmborg, Qihua Tan,
https://doi.org/10.18632/aging.104198 pp 22457—22494
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Cell differentiation and aging accompanied by depletion of the ACE2 protein

Eva Bártová, Soňa Legartová, Jana Krejčí, Orazio Angelo Arcidiacono,
https://doi.org/10.18632/aging.202221 pp 22495—22508
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Comprehensive characterization of the tumor microenvironment for assessing immunotherapy outcome in patients with head and neck squamous cell carcinoma

Jian Zhang, Xi Zhong, Huali Jiang, Hualong Jiang, Tao Xie, Yunhong Tian, Rong Li, Baiyao Wang, Jiexia Zhang, Yawei Yuan,
https://doi.org/10.18632/aging.103460 pp 22509—22526
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Cationic solid lipid nanoparticles loaded by integrin β1 plasmid DNA attenuates IL-1β-induced apoptosis of chondrocyte

Yuejiang Zhao, Hanwen Chen, Lu Wang, Zhiyuan Guo, Shijie Liu, Simin Luo,
https://doi.org/10.18632/aging.103656 pp 22527—22537
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Inflammatory factors and amyloid β-induced microglial polarization promote inflammatory crosstalk with astrocytes

Lushuang Xie, Ning Zhang, Qun Zhang, Chenyu Li, Aaron F. Sandhu, George Williams III, Sirui Lin, PeiRan Lv, Yi Liu, Qiaofeng Wu, Shuguang Yu,
https://doi.org/10.18632/aging.103663 pp 22538—22549
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The therapeutic value of XL388 in human glioma cells

Shan Zhong, Jun Xue, Jiao-Jiao Cao, Bomin Sun, Qing-Fang Sun, Liu-Guan Bian, Liang-Yun Hu, Si-Jian Pan,
https://doi.org/10.18632/aging.103791 pp 22550—22563
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Upregulated GDF-15 expression facilitates pancreatic ductal adenocarcinoma progression through orphan receptor GFRAL

Zhiping Zhao, Junfeng Zhang, Liangyu Yin, Jiali Yang, Yao Zheng, Mengjie Zhang, Bing Ni, Huaizhi Wang,
https://doi.org/10.18632/aging.103830 pp 22564—22581
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linc00968 inhibits the tumorigenesis and metastasis of lung adenocarcinoma via serving as a ceRNA against miR-9-5p and increasing CPEB3

Huaping Tang, Xiaolei Han, Yan Feng, Yueqin Hao,
https://doi.org/10.18632/aging.103833 pp 22582—22598
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miR-25-3p promotes endothelial cell angiogenesis in aging mice via TULA-2/SYK/VEGFR-2 downregulation

Chong Lian, Lei Zhao, Jiacong Qiu, Yang Wang, Rencong Chen, Zhen Liu, Jin Cui, Xiaonan Zhu, Xuejun Wen, Shenming Wang, Jinsong Wang,
https://doi.org/10.18632/aging.103834 pp 22599—22613
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The relationship between activities of daily living and suicidal ideation among Chinese rural older adults: a multiple mediation model through sleep quality and psychological distress

Dan Zhao, Jie Li, Wenting Hao, Yemin Yuan, Caiting Yu, Zhengyue Jing, Yi Wang, Peipei Fu, Chengchao Zhou,
https://doi.org/10.18632/aging.103857 pp 22614—22625
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Colon cancer-specific diagnostic and prognostic biomarkers based on genome-wide abnormal DNA methylation

Yilin Wang, Ming Zhang, Xiaoyun Hu, Wenyan Qin, Huizhe Wu, Minjie Wei,
https://doi.org/10.18632/aging.103874 pp 22626—22655
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Long non-coding RNA ZFAS1 promotes colorectal cancer tumorigenesis and development through DDX21-POLR1B regulatory axis

Xiufang Wang, Zhikun Wu, Wenyan Qin, Tong Sun, Senxu Lu, Yalun Li, Yuanhe Wang, Xiaoyun Hu, Dongping Xu, Yutong Wu, Qiuchen Chen, Weifan Yao, Mingyan Liu, Minjie Wei, Huizhe Wu,
https://doi.org/10.18632/aging.103875 pp 22656—22687
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Glycemic traits and Alzheimer’s disease: a Mendelian randomization study

Yuesong Pan, Weiqi Chen, Hongyi Yan, Mengxing Wang, Xianglong Xiang,
https://doi.org/10.18632/aging.103887 pp 22688—22699
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Drug-selected population in melanoma A2058 cells as melanoma stem-like cells retained angiogenic features – the potential roles of heparan-sulfate binding ANGPTL4 protein

Chia-Yu Shih, Yu-Che Cheng, ChiaoHui Hsieh, TingTing Tseng, ShihSheng Jiang, Shao-Chen Lee,
https://doi.org/10.18632/aging.103890 pp 22700—22718
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Gonadal white adipose tissue-derived exosomal MiR-222 promotes obesity-associated insulin resistance

Dameng Li, Huichen Song, Linghu Shuo, Lei Wang, Ping Xie, Weili Li, Jiachen Liu, Yafei Tong, Chen-Yu Zhang, Xiaohong Jiang, Jing Li, Yujing Zhang,
https://doi.org/10.18632/aging.103891 pp 22719—22743
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Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ

Jinhong Liu, Ning Zhao, Guiling Shi, Hai Wang,
https://doi.org/10.18632/aging.103902 pp 22744—22758
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NEAT1/miR-200b-3p/SMAD2 axis promotes progression of melanoma

Wen-Jie Zhou, Hao-Yu Wang, Jie Zhang, Hai-Ying Dai, Zhi-Xian Yao, Zhong Zheng, Sun Meng-Yan, Ke Wu,
https://doi.org/10.18632/aging.103909 pp 22759—22775
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Immune-related biomarker risk score predicts prognosis in prostate cancer

Zezhen Liu, Jiehui Zhong, Chao Cai, Jianming Lu, Wenqi Wu, Guohua Zeng,
https://doi.org/10.18632/aging.103921 pp 22776—22793
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Integrative analysis of transcriptomes highlights potential functions of transfer-RNA-derived small RNAs in experimental intracerebral hemorrhage

Peng-Fei Li, Shi-Chao Guo, Tao Liu, Hanjin Cui, Dandan Feng, Ali Yang, Zhe Cheng, Jiekun Luo, Tao Tang, Yang Wang,
https://doi.org/10.18632/aging.103938 pp 22794—22813
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Analysis of DNA methylation-driven genes for predicting the prognosis of patients with colorectal cancer

Boshi Fu, Cheng Du, Zhikun Wu, Mingwei Li, Yi Zhao, Xinli Liu, Huizhe Wu, Minjie Wei,
https://doi.org/10.18632/aging.103949 pp 22814—22839
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Establishing and validating a pathway prognostic signature in pancreatic cancer based on miRNA and mRNA sets using GSVA

Junfeng Zhang, Jianyou Gu, Shixiang Guo, Wenjie Huang, Yao Zheng, Xianxing Wang, Tao Zhang, Weibo Zhao, Bing Ni, Yingfang Fan, Huaizhi Wang,
https://doi.org/10.18632/aging.103965 pp 22840—22858
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Identification of novel FUS and TARDBP gene mutations in Chinese amyotrophic lateral sclerosis patients with HRM analysis

Feng Wang, Shengyu Fu, Jiafan Lei, Hongchen Wu, Shugui Shi, Kangning Chen, Jun Hu, Xueqing Xu,
https://doi.org/10.18632/aging.103967 pp 22859—22868
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Global burden and trend of acute lymphoblastic leukemia from 1990 to 2017

Ming Yi, Linghui Zhou, Anping Li, Suxia Luo, Kongming Wu,
https://doi.org/10.18632/aging.103982 pp 22869—22891
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USP10 deletion inhibits macrophage-derived foam cell formation and cellular-oxidized low density lipoprotein uptake by promoting the degradation of CD36

Xiaohong Xia, Tumei Hu, Jinchan He, Qiong Xu, Cuifu Yu, Xiaolin Liu, Zhenlong Shao, Yuning Liao, Hongbiao Huang, Ningning Liu,
https://doi.org/10.18632/aging.104003 pp 22892—22905
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Construction of immune-related gene pairs signature to predict the overall survival of osteosarcoma patients

Long-Qing Li, Liang-Hao Zhang, Yan Zhang, Xin-Chang Lu, Yi Zhang, Yong-Kui Liu, Manhas Abdul Khader, Jia-Wen, Tao-Liu, Jia-Zhen Li,
https://doi.org/10.18632/aging.104017 pp 22906—22926
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Cause of death among patients with colorectal cancer: a population-based study in the United States

Jiayuan Chen, Yongqiang Zheng, Haihong Wang, Dejun Zhang, Lei Zhao, Dandan Yu, Zhenyu Lin, Tao Zhang,
https://doi.org/10.18632/aging.104022 pp 22927—22948
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In vitro and in vivo efficacy of the novel oral proteasome inhibitor NNU546 in multiple myeloma

Hui Zhou, Meng Lei, Wang Wang, Mengjie Guo, Jia Wang, Haoyang Zhang, Li Qiao, Huayun Feng, Zhaogang Liu, Lijuan Chen, Jianhao Hou, Xueyuan Wang, Chenxi Gu, Bo Zhao, Evgeny Izumchenko, Ye Yang, Yongqiang Zhu,
https://doi.org/10.18632/aging.104023 pp 22949—22974
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Silencing KIF14 reverses acquired resistance to sorafenib in hepatocellular carcinoma

Qiankun Zhu, Haiyang Ren, Xiaodong Li, Bo Qian, Shengjie Fan, Fengli Hu, Lishan Xu, Bo Zhai,
https://doi.org/10.18632/aging.104028 pp 22975—23003
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Patrolling monocytes inhibit osteosarcoma metastasis to the lung

Ting Chen, Lin Zhao,
https://doi.org/10.18632/aging.104041 pp 23004—23016
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Autophagy is induced in human keratinocytes during human papillomavirus 11 pseudovirion entry

Rui Han, Chunting Hua, Siyuan Sun, Boya Zhang, Yinjing Song, Stijn van der Veen, Hao Cheng,
https://doi.org/10.18632/aging.104046 pp 23017—23028
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ERRα inhibitor acts as a potential agonist of PPARγ to induce cell apoptosis and inhibit cell proliferation in endometrial cancer

Meimei Huang, Lili Chen, Xiaodan Mao, Guifen Liu, Yuqin Gao, Xiaoqing You, Min Gao, Jalid Sehouli, Pengming Sun,
https://doi.org/10.18632/aging.104049 pp 23029—23046
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Circulating non-coding RNA cluster predicted the tumorigenesis and development of colorectal carcinoma

Jie Li, Yifei Feng, Ding Heng, Ranran Chen, Yong Wang, Ziwei Xu, Dongsheng Zhang, Chuan Zhang, Yue Zhang, Dongjian Ji, Junwei Tang, Yueming Sun,
https://doi.org/10.18632/aging.104055 pp 23047—23066
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CD138- multiple myeloma cells express high level of CHK1 which correlated to overall survival in MM patient

Dong Wu, Peihua Zhang, Fangmei Li, Ying Shen, Hongli Chen, Yuandong Feng, Aili He, Fangxia Wang,
https://doi.org/10.18632/aging.104066 pp 23067—23081
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Deubiquitinase USP7 regulates Drosophila aging through ubiquitination and autophagy

Lang Cui, Wenhao Song, Yao Zeng, Qi Wu, Ziqiang Fan, Tiantian Huang, Bo Zeng, Mingwang Zhang, Qingyong Ni, Yan Li, Tao Wang, Diyan Li, Xueping Mao, Ting Lian, Deying Yang, Mingyao Yang, Xiaolan Fan,
https://doi.org/10.18632/aging.104067 pp 23082—23095
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Protective effect of DLX6-AS1 silencing against cerebral ischemia/reperfusion induced impairments

Xiamin Hu, Zifei Xiang, Wei Zhang, Zhijun Yu, Xiaoming Xin, Rong Zhang, Youping Deng, Qiong Yuan,
https://doi.org/10.18632/aging.104070 pp 23096—23113
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Intracellular and extracellular S100A9 trigger epithelial-mesenchymal transition and promote the invasive phenotype of pituitary adenoma through activation of AKT1

Ning Huang, Guanjian Zhao, Qiang Yang, Jiahe Tan, Ying Tan, Jiqin Zhang, Yuan Cheng, Jin Chen,
https://doi.org/10.18632/aging.104072 pp 23114—23128
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Cognitive frailty in relation to adverse health outcomes independent of multimorbidity: results from the China health and retirement longitudinal study

Chen Chen, JuYoung Park, Chenkai Wu, QianLi Xue, George Agogo, Ling Han, Emiel O. Hoogendijk, Zuyun Liu, Zunyou Wu,
https://doi.org/10.18632/aging.104078 pp 23129—23145
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pSynGAP1 disturbance-mediated hippocampal oscillation network impairment might contribute to long-term neurobehavioral abnormities in sepsis survivors

Yong Wang, Hua Wei, Jianhua Tong, Muhuo Ji, Jianjun Yang,
https://doi.org/10.18632/aging.104080 pp 23146—23164
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An eleven metabolic gene signature-based prognostic model for clear cell renal cell carcinoma

Yue Wu, Xian Wei, Huan Feng, Bintao Hu, Bo Liu, Yang Luan, Yajun Ruan, Xiaming Liu, Zhuo Liu, Shaogang Wang, Jihong Liu, Tao Wang,
https://doi.org/10.18632/aging.104088 pp 23165—23186
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Identification and characterization of dynamically regulated hepatitis-related genes in a concanavalin A-induced liver injury model

Anna Chen, Yidong Wang, Jiaqi Wu, Dong Tang, Qianru Zhu, Anqian Lu, Jin Yang, Zhejun Cai, Junping Shi,
https://doi.org/10.18632/aging.104089 pp 23187—23199
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Development and validation of a nomogram with an epigenetic signature for predicting survival in patients with lung adenocarcinoma

Jiao Wang, Li He, Yunliang Tang, Dan Li, Yuting Yang, Zhenguo Zeng,
https://doi.org/10.18632/aging.104090 pp 23200—23216
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Alteration of tumor-associated macrophage subtypes mediated by KRT6A in pancreatic ductal adenocarcinoma

Junfeng Zhang, Hui Sun, Songsong Liu, Wenjie Huang, Jianyou Gu, Zhiping Zhao, Huan Qin, Liwen Luo, Jiali Yang, Yongfei Fang, Jiayun Ge, Bing Ni, Huaizhi Wang,
https://doi.org/10.18632/aging.104091 pp 23217—23232
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NEAT1 regulates microtubule stabilization via FZD3/GSK3β/P-tau pathway in SH-SY5Y cells and APP/PS1 mice

Yiwan Zhao, Ziqiang Wang, Yunhao Mao, Bing Li, Yuanchang Zhu, Shikuan Zhang, Songmao Wang, Yuyang Jiang, Naihan Xu, Yizhen Xie, Weidong Xie, Yaou Zhang,
https://doi.org/10.18632/aging.104098 pp 23233—23250
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Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma

Xin Zhao, Xinxue Zhang, Zhigang Zhang, Zhe Liu, Jiqiao Zhu, Shaocheng Lyu, Lixin Li, Ren Lang, Qiang He,
https://doi.org/10.18632/aging.104099 pp 23251—23274
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Transcriptome profiling reveals an integrated mRNA–lncRNA signature with predictive value for long-term survival in diffuse large B-cell lymphoma

Qian Gao, Zhiyao Li, Lingxian Meng, Jinsha Ma, Yanfeng Xi, Tong Wang,
https://doi.org/10.18632/aging.104100 pp 23275—23295
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Inverse association between periumbilical fat and longevity mediated by complement C3 and cardiac structure

Shihui Fu, Yao Yao, Shengzheng Wu, Juelin Deng, Faqin Lv, Yali Zhao,
https://doi.org/10.18632/aging.104113 pp 23296—23305
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Identification of immune-related LncRNA for predicting prognosis and immunotherapeutic response in bladder cancer

Yucai Wu, Lei Zhang, Shiming He, Bao Guan, Anbang He, Kunlin Yang, Yanqing Gong, Xuesong Li, Liqun Zhou,
https://doi.org/10.18632/aging.104115 pp 23306—23325
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The DLG1-AS1/miR-497/YAP1 axis regulates papillary thyroid cancer progression

Yong Huang, KeWei Zhang, Yinghua Li, Yuyin Dai, Hongguang Zhao,
https://doi.org/10.18632/aging.104121 pp 23326—23336
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Intratumoral levels and prognostic significance of Fusobacterium nucleatum in cervical carcinoma

Shu-Ting Huang, Jing Chen, Li-Yin Lian, Hui-Hua Cai, Hai-Shan Zeng, Min Zheng, Mu-Biao Liu,
https://doi.org/10.18632/aging.104188 pp 23337—23350
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Cognitive reserve and network efficiency as compensatory mechanisms of the effect of aging on phonemic fluency

Lissett Gonzalez-Burgos, José Barroso, Daniel Ferreira,
https://doi.org/10.18632/aging.202177 pp 23351—23378
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Reviews

Radiation-induced skin injury: pathogenesis, treatment, and management

Xiaojing Yang, Hanru Ren, Xiaomao Guo, Chaosu Hu, Jie Fu,
https://doi.org/10.18632/aging.103932 pp 23379—23393
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Circulating plasma factors involved in rejuvenation

Jae Sook Kang, Yong Ryoul Yang,
https://doi.org/10.18632/aging.103933 pp 23394—23408
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COVID-19
Impact of cardiovascular and metabolic diseases on the severity of COVID-19: a systematic review and meta-analysis

Meng Meng, Qianwen Zhao, Rahul Kumar, Chen Bai, Yunlei Deng, Bo Wan,
https://doi.org/10.18632/aging.103991 pp 23409—23421
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