Review Volume 12, Issue 15 pp 15818—15855

The role of Anaphase Promoting Complex activation, inhibition and substrates in cancer development and progression

Figure 3. Protein activators of the APC that function through CDC20 and/or CDH1. The BioGRID database was searched for CDC20 and CDH1 interactors. All protein nodes identified were searched using PubMed. Proteins found to activate the APC, but not serve as substrates, are shown here. Proteins unique to CDC20 are shown in red, those unique to CDH1 are shown in blue, and those identified in both searches are shown in green. PARKIN, when phosphorylated by PLK1, is believed to recruit CDC20 and CDH1 to ubiquitinate APC substrates. Ph, phosphorylation; Ac, acetylation; Ub, ubiquitination.