Research Paper Volume 12, Issue 21 pp 21161—21185

Tim-3 deteriorates neuroinflammatory and neurocyte apoptosis after subarachnoid hemorrhage through the Nrf2/HMGB1 signaling pathway in rats

Figure 10. Administration of NK252 reversed the brain edema, BBB disruption associated with Tim-3 after SAH. Representative images of H&E staining showing alterations in lesion volume after NK252 treatment (A). NK252 treatment significantly decreased BWC (B) and Evans Blue dye extravasation (C) at 24 h post-SAH(n = 6 in each group). Data are expressed as the mean ± SEM.*p < 0.05,**p < 0.01, ***p < 0.001. Scale bar = 50 μm.