Research Paper Volume 12, Issue 21 pp 21161—21185

Tim-3 deteriorates neuroinflammatory and neurocyte apoptosis after subarachnoid hemorrhage through the Nrf2/HMGB1 signaling pathway in rats

Figure 3. The effect of AAV-Tim-3 on brain edema, BBB disruption, and neurological function after SAH. AAV-Tim-3 treatment significantly increased brain water content (BWC) (A) and Evans Blue dye extravasation (B) at 24 h post-SAH and exacerbated neurological deficits (C) (n = 6/group). Representative images of H&E staining (D) showing alterations in lesion volume after AAV-Tim-3 treatment. Data are expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001. BS, brain stem; Cb, cerebellum; LH, left hemisphere; RH, right hemisphere.