Research Paper Volume 12, Issue 21 pp 21161—21185

Tim-3 deteriorates neuroinflammatory and neurocyte apoptosis after subarachnoid hemorrhage through the Nrf2/HMGB1 signaling pathway in rats

Figure 6. The effect of Tim-3 knockdown on brain edema, BBB disruption, neurological function, and inflammatory cytokine production after SAH. Tim-3 siRNA treatment significantly decreased BWC (A) and Evans Blue dye extravasation (B) at 24 h post-SAH and improved neurological function (C) (n = 6 in each group). Tim-3 siRNA treatment decreased the expression of the inflammatory cytokines, IL-1β (D), IL-17 (E), and IL-18 (F) TNF-α (G). Data are expressed as the mean ± SEM.*p < 0.05,**p < 0.01, ***p < 0.001.