Research Paper Volume 12, Issue 21 pp 21161—21185

Tim-3 deteriorates neuroinflammatory and neurocyte apoptosis after subarachnoid hemorrhage through the Nrf2/HMGB1 signaling pathway in rats

Figure 9. NK252 treatment abolished neurocyte apoptosis and the inflammatory effects associated with Tim-3. TUNEL staining showing that NK252 treatment significantly decreased TUNEL-positive neurocyte (A) and the expression of the pro-inflammatory cytokines, IL-1β (B), IL-17 (C), and IL-18 (D) TNF-α (E) (n = 6 in each group). Data are expressed as the mean ± SEM.*p < 0.05,**p < 0.01. Scale bar = 50 μm.