Research Paper Volume 12, Issue 20 pp 20308—20331
TRIM28 is a distinct prognostic biomarker that worsens the tumor immune microenvironment in lung adenocarcinoma
TRIM28 levels in different human cancer types. (A) Increased or reduced TRIM28 levels in different cancers compared with normal tissues in the Oncomine database. (B) Human TRIM28 levels in different tumor types from TCGA were determined using TIMER. (C–F) The significant increase in TRIM28 expression in LUAD was further validated in GSE32863 (C), GSE7670 (D), the Beer Lung dataset (E) and GSE19188 (F). (G) The protein expression of TRIM28 in various cancer tissues was detected using the UALCAN cancer database (*p < 0.05, **p < 0.01, ***p < 0.001). TCGA, The Cancer Genome Atlas; LUAD, lung adenocarcinoma; UCEC, uterine corpus endometrial carcinoma; GSE, Gene Expression Omnibus data series.