Research Paper Volume 12, Issue 19 pp 19352—19364

CircPDZD8 promotes gastric cancer progression by regulating CHD9 via sponging miR-197-5p

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Effect of circPDZD8 on progress of gastric cancer cells. (A, B) circPDZD8 expression in SGC-7901 and MGC-803 cells transfected with si-circPDZD8-1, si-circPDZD8-2 or si-NC was examined by RT-qPCR. (C, D) The proliferation of SGC-7901 and MGC-803 cells transfected with si-circPDZD8-1, si-circPDZD8-2 or si-NC was measured by MTT assay. (E) Clone formation assay demonstrated the clone number in the circPDZD8 knockdown transfection group and the control transfection. (F) The migration of SGC-7901 and MGC-803 cells transfected with si-circPDZD8-1, si-circPDZD8-2 or si-NC was examined by Transwell assay without Matrigel. (G) Representative images of migrated cells in the Transwell migration assay; *** P < 0.001.