Figure 1. Constructing the profile for Alzheimer’s disease risk variants of the PICALM gene via systematic review and meta-analysis. The flow chart of the literature selection: Finally, a total of 44 case-control studies were included, with 59 loci within or near PICALM gene associated with AD risk (A). The majority of included studies had a small-to-moderate sample size < 5000 (mainly from Asian, African, and Hispanic populations) and and the minority had a larger sample from Caucasian population or mixed-race population based on multi-center organizations (B). Associations of PICALM variations with AD risk in different populations (C).