Research Paper Volume 12, Issue 20 pp 20380—20395

Rab1A promotes cancer metastasis and radioresistance through activating GSK-3β/Wnt/β-catenin signaling in nasopharyngeal carcinoma

Figure 1. Rab1A is highly expressed in NPC and positively correlates with poor prognosis of NPC patients. (A) Shown are representative immunohistochemistry (IHC) staining of Rab1A in NPC and non-cancerous nasopharyngitis (NP) tissues. Lower panels represent magnified images of boxed area in the corresponding upper panel. The full line and dotted line scale represent 100 μm and 50 μm. (B) Comparsion of Rab1A expression between NPC tissues and NP tissues. The expression of Rab1A mRNA was upregulated in the Gene Expression Omnibus (GEO) database (C) GSE12452 and (D) GSE12597. (EG) The expression of Rab1A in NPC patients with different T stage, different TNM stage or with/without distant metastasis. (H) Kaplan-Meier survival curve of OS in NPC patients with high (n=55) and low (n=51) levels of Rab1A expression. NPC patients with high expression of Rab1A have shorter OS than patients with low expression (P < 0.0001).