Research Paper Volume 12, Issue 22 pp 22582—22598

linc00968 inhibits the tumorigenesis and metastasis of lung adenocarcinoma via serving as a ceRNA against miR-9-5p and increasing CPEB3

Figure 2. linc00969 inhibits LUAD cell growth. (A) The levels of linc00968 in linc00968 overexpressing A549 and H1975 cell or linc00968 knockdown in HCC827 were detected with qRT-PCR assay, (B) CCK-8 assays showed that overexpression of linc00968 inhibited cell proliferation in A549 and H1975 cell, whereas knockdown of linc00968 increased cell proliferation in HCC827 cell. (C) Colony-forming assays showed that linc00968 reduced A549 and H1975 colony formation, whereas knockdown of linc00968 enhanced the colony formation of HCC827 cell. (D) Representative images and the percentage of migration in wound healing assay. (E) Representative images and the number of invading cells in Transwell invasion assay. (F) The expressions of E-cadherin and N-cadherin were detected using western blotting assay. **P<0.01 versus pcDNA3.1 or si-Ctrl.