Research Paper Volume 12, Issue 22 pp 22582—22598

linc00968 inhibits the tumorigenesis and metastasis of lung adenocarcinoma via serving as a ceRNA against miR-9-5p and increasing CPEB3

Figure 8. Overexpression of linc00968 suppresses the growth of A549 cell in vivo. (A) The respective xenograft tumors from the nude mice were exhibited. Tumor weights and tumor growth curves were analyzed. (B) IHC of CPEB3 in the subcutaneous tumors. Scale bar, 200 μm. (C) The expressions of E-cadherin and N-cadherin were detected using western blotting assay. (D) Representative photos for lung metastasis nodules. The number of nodules lung metastatic foci as calculated. (E) CPEB3 expression in TCGA, with red boxplot referring to LUAD sample and gray boxplot referring to normal sample. (F) Survival analysis of CPEB3 in LUAD from TCGA. (G) The correlations between CPEB3 and miR-9-5p or linc00968 were analyzed in TCGA. **P<0.01 versus pcDNA3.1.