Research Paper Volume 12, Issue 22 pp 22599—22613

miR-25-3p promotes endothelial cell angiogenesis in aging mice via TULA-2/SYK/VEGFR-2 downregulation

Figure 3. TULA-2 is the downstream target of miR-25-3p. (A) The predicted and conserved miR-25-3p target sites in the 3’UTR of TULA-2. (B) The luciferase activity of the WT 3’UTR but not the mutated 3’ UTR of TULA-2 was downregulated by miR-25-3p mimics in ECs (**P < 0.01 versus the negative control).