Research Paper Volume 12, Issue 18 pp 18561—18570

Chetomin rescues pathogenic phenotype of LRRK2 mutation in drosophila

Figure 3. PRDX2 is able to rescue G2019S pathogenic phenotype. (A) Representative magnified confocal images of whole mount brains 60 days after eclosion. The different clusters of TH+ neurons are boxed up and labeled. (B) Bar graphs show number of TH-positive DA neuron clusters in flies at 60 days after eclosion (n = 3, cohort of 10). (C) Bar graph shows climbing scores of male flies at 60 days after eclosion. Percentage of flies that reached the top of the column after 1 min was counted (n = 3, cohort of 20). (D) Bar graph shows number of flies that survive after 60 days. Age-matched ddc-GAL4/+ flies were used as controls. Percentage of flies was tabulated. Significance indicated on the graph: *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.