Research Paper Volume 12, Issue 18 pp 18561—18570

Chetomin rescues pathogenic phenotype of LRRK2 mutation in drosophila

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Figure 3. PRDX2 is able to rescue G2019S pathogenic phenotype. (A) Representative magnified confocal images of whole mount brains 60 days after eclosion. The different clusters of TH+ neurons are boxed up and labeled. (B) Bar graphs show number of TH-positive DA neuron clusters in flies at 60 days after eclosion (n = 3, cohort of 10). (C) Bar graph shows climbing scores of male flies at 60 days after eclosion. Percentage of flies that reached the top of the column after 1 min was counted (n = 3, cohort of 20). (D) Bar graph shows number of flies that survive after 60 days. Age-matched ddc-GAL4/+ flies were used as controls. Percentage of flies was tabulated. Significance indicated on the graph: *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.