Research Paper Volume 12, Issue 20 pp 20457ā€”20470

Designing high affinity target-binding peptides to HLA-E: a key membrane antigen of multiple myeloma

Figure 1. HLA-E is a key gene in MM. (A) Identification of upregulated DEGs in GSE6691 and GSE39754 datasets (Log2FC >1.5, P < 0.05). (B) The protein-protein interaction (PPI) network between co-upregulated DEGs in MM. (Cā€“E). Modules in the PPI network with scores >4 and HLA-E in the cluster 3 (Figure 1E). (F). HLA-E is one of the hub genes in PPI network. (G) Overlapping genes between the key clusters and hub genes.