Research Paper Volume 12, Issue 21 pp 21344—21354

Soy isoflavones ameliorate the cognitive dysfunction of Goto-Kakizaki rats by activating the Nrf2-HO-1 signalling pathway

Figure 2. Effect of SIF on the spatial memory of diabetic rats. (A) Time (seconds) spent finding the platform submerged under the water at days 1-4; (B) Exploration time (seconds) spent in the target quadrant that contained the platform at day 5; (C)The rats in all three groups displayed no difference in swim speed. (D) The number of times the rats crossed the target quadrant. (E) The percentage of self-changing behavior in the Y maze of the rats. The results are shown as the mean±standard deviation (n=10 per group). *p < 0.05 or ##p <0.01vs. the CON group, #p <0.05 or ##p <0.01 vs. the DM group.