Research Paper Volume 12, Issue 22 pp 22700—22718

Drug-selected population in melanoma A2058 cells as melanoma stem-like cells retained angiogenic features – the potential roles of heparan-sulfate binding ANGPTL4 protein

Figure 1. Selected drug-resistant cells from melanoma A2058 cells showed reduced cell invasiveness and cell proliferation. (A) appearance of cell aggregates or cell spheres under detachment-impaired suspension cultures of different melanoma cells. (B) Difference in the phenotypes of elongated parental and pyramid-shaped drug-selected cells. (C) Comparison of transwell cell migration ability between parental and drug-selected cells show low cell invasiveness in drug-selected cells. (D) cell proliferation was slower in drug-selected cells than in parental cells.