Research Paper Volume 12, Issue 22 pp 22719—22743

Gonadal white adipose tissue-derived exosomal MiR-222 promotes obesity-associated insulin resistance

Figure 8. Excessive secretion of gWAT-derived exosomal miR-222 promotes obesity-induced insulin resistance. Upregulation of circulating gWAT-derived exosomal miR-222 promote insulin resistance by repressing IRS-1 expression in the liver and skeletal muscle tissues of the HFD-fed obese model mice.