Figure 1. Hypoxia-induced PASMC dysfunction. (A) Hypoxia increased mean pulmonary artery pressure (mPAP) in rats. (B) Hypoxia increased pulmonary vessel resistance (PVR) in rats. (C) PE-induced vasoconstriction presented as percentage of maximal contraction. (D) PE-induced vasoconstriction presented as contraction force per tissue weight (g/mg tissue). (E, F) Both endothelium-dependent (E) and endothelium-independent (F) vasodilation was impaired in hypoxic rats. *, p<0.05, **, p<0.01. n=8.