Research Paper Volume 12, Issue 21 pp 21404—21422

CPEB3 functions as a tumor suppressor in colorectal cancer via JAK/STAT signaling

Figure 2. CPEB3 inhibits human colorectal cancer proliferation in vitro. (A) CPEB3 protein expressions of CRC cell lines were efficiently upregulated or downregulated after transfection as analyzed by Western blotting (left) and qPCR (right) detection (**P < 0.01, ***P < 0.001). (B, C) After effective up- or down-regulation of CPEB3, CCK-8 (B) and colony formation (C) assays were performed to explore the effect of CPEB3 on proliferative capacity of colorectal cancer cell line.