Research Paper Volume 12, Issue 21 pp 21404—21422

CPEB3 functions as a tumor suppressor in colorectal cancer via JAK/STAT signaling

Figure 5. CPEB3 inhibits human colorectal cancer proliferation and JAK/STAT pathway in vivo. (A) Representative images of tumors formed in nude mice subcutaneously implanted with SW480-CPEB3, SW-NC, SW480-shCPEB3 and SW480-shCtrl cell lines. (B) Growth curves of implanted tumors in nude mice (**P< 0.01, ***P< 0.001). (C) Representative immunohistochemical images of tumor xenografts derived from SW480-CPEB3, SW-NC, SW480-shCPEB3 and SW480-shCtrl cell lines stained by anti-CD31 and anti-Ki67 antibodies (Original magnification, ×200). (D) Western blots showed that CPEB3 overexpression suppressed JAK1 and phosphorylated JAK1, as well as molecules in the JAK/STAT pathway while CPEB3 knockdown promoted the activation of these genes.