Research Paper Advance Articles pp 23698—23726

The ZiBuPiYin recipe regulates proteomic alterations in brain mitochondria-associated ER membranes caused by chronic psychological stress exposure: Implications for cognitive decline in Zucker diabetic fatty rats

Figure 3. Effects of ZBPYR on behavioral performance of treatment in PSD rats. The OFT was performed during day 1 and the MWM was performed during days 2-7 of the last seven days. Spontaneous locomotor activities were recorded in the OFT, including total distance moved (A), number of center zone entries (B), time spent in the center (C), and vertical number (D). (E) Escape latencies were analyzed in the training trials of the MWM. Performance in the probe test was analyzed, including the percentage of time spent in the target quadrant (F), crossing number of the original platform location (G), probe time searching for the original platform location (H), and the distance traveled to the original platform location (I). (J) Escape latency in the visible platform version of the MWM was analyzed. *p <0.05, **p <0.01, ***p <0.001, ****p <0.0001 PSD vs. ZDF; #p <0.05, ##p <0.01, ####p <0.0001, PDZ vs. PSD (mean ± SEM, n=8 per group).