Research Paper Volume 12, Issue 22 pp 22744—22758

Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ

Figure 1. Effect of GE on sepsis-induced kidney injury. Sepsis-induced kidney injury model in BALB/c mice was conducted using cecal ligation and puncture (CLP) surgery, and the mice were received GE 1 h after the CLP surgery at different doses (10 mg/kg, 20 mg/kg and 40 mg/kg) three times (once every 6 h). 24 h after the surgery, H&E staining and PAS staining were performed to observe the histopathological changes (A, B). The histological injury was quantified (C). ***p<0.001 vs="" the="" sham="" group.="" ###p<0.001="" CLP="" group.<="" p="">