Research Paper Volume 12, Issue 20 pp 20512—20522

RWR-algorithm-based dissection of microRNA-506-3p and microRNA-140-5p as radiosensitive biomarkers in colorectal cancer

Figure 5. Validation of the association between hsa-mir-506-3p and hsa-mir-140-5p and the radiosensitivity in colorectal cancer. (A) Plasma expression levels of hsa-mir-506-3p and hsa-mir-140-5p between radiosensitive and radioresistant patients. (B) Transfection efficiency of hsa-mir-506-3p mimic and hsa-mir-140-5p mimic. (C) Survival curves of transfected cells with hsa-mir-506-3p mimic and hsa-mir-140-5p mimic, negative control and untransfected cells at 0, 2, 4 and 6Gy radiation. (D) Cell proliferation assay analysis of transfected cells with hsa-mir-506-3p mimic and hsa-mir-140-5p mimic, negative control and untransfected cells after 4Gy radiation. (E) Clone forming assay analysis of transfected cells with hsa-mir-506-3p mimic and hsa-mir-140-5p mimic, negative control and untransfected cells after 4Gy radiation. Compared with the control or negative control, *P<0.05, **P<0.01, ***P<0.001.