Research Paper Volume 12, Issue 21 pp 21469—21480

The protective effects of memantine against inflammation and impairment of endothelial tube formation induced by oxygen-glucose deprivation/reperfusion

Figure 3. Memantine restored oxygen-glucose deprivation/reperfusion-induced reduction of mitochondrial membrane potential (ΔΨm) in human umbilical vein endothelial cells (HUVECs). Cells were treated with memantine (5, 10 μM) for 6 h, followed by exposure to oxygen-glucose deprivation (6 h)/reperfusion (24 h) (OGD/R). Intracellular ΔΨm was measured by rhodamine 123 (RH123) (####, P<0.0001 vs. vehicle group; ***, *****, P<0.001, 0.0001 vs OGD/R group).