Research Paper Volume 12, Issue 21 pp 21469—21480

The protective effects of memantine against inflammation and impairment of endothelial tube formation induced by oxygen-glucose deprivation/reperfusion

Figure 5. Memantine increased the expression of Nrf2 and HO-1 under OGD/R in HUVECs. Cells were treated with memantine (5, 10 μM) for 6 h, followed by exposed to oxygen-glucose deprivation (6 h)/reperfusion (24 h) (OGD/R). Expressions of Nrf2 and HO-1 were measured by western blot analysis (####, P<0.0001 vs. vehicle group; ***, *****, P<0.001, 0.0001 vs OGD/R group).