Research Paper Volume 12, Issue 21 pp 21469—21480

The protective effects of memantine against inflammation and impairment of endothelial tube formation induced by oxygen-glucose deprivation/reperfusion

Figure 6. Memantine protected oxygen-glucose deprivation/reperfusion (OGD/R)-induced cell death in HUVECs. Cells were treated with memantine (5, 10 μM) for 6 h, followed by exposure to oxygen-glucose deprivation (6 h)/reperfusion (24 h) (OGD/R). (A) Cell morphology of HUVECs; Scale bar, 100 μm; (B) LDH release (####, P<0.0001 vs. vehicle group; ***, *****, P<0.001, 0.0001 vs OGD/R group).