Research Paper Volume 12, Issue 19 pp 19585—19596

Glypican-1-targeted and gemcitabine-loaded liposomes enhance tumor-suppressing effect on pancreatic cancer

Figure 5. GPC1-LP (GEM) inhibited tumor growth of the orthotopic pancreatic cancer mice. (A) The weight changes of the orthotopic pancreatic cancer mice treated with saline (control), LP, GPC1-LP, GEM, LP (GEM) and GPC1-LP (GEM). (B) The tumor weight of the orthotopic pancreatic cancer mice treated with saline (control), LP, GPC1-LP, GEM, LP (GEM) and GPC1-LP (GEM). (C) The correlation between GPC1 mRNA and hypoxia in pancreatic cancer was detected by TCGA database. (D) qRT-PCR was used to detect mRNA expression levels of tumor tissues and genes associated with hypoxia. *p<0.05.