Research Paper Volume 12, Issue 21 pp 21518—21543

Oncostatin M expression and TP53 mutation status regulate tumor-infiltration of immune cells and survival outcomes in cholangiocarcinoma

Figure 2. Identify the differentially expressed genes (DEGs) of three datasets, and the pathway and process enrichment analysis of overlapped DEGs between CCA and precancerous tissues. (A) Volcano plot and heatmap of 5 pairs matched CCA and precancerous tissues from our own RNA high-through sequencing data; (B) Venn diagram for overlapped DEGs of TCGA, GSE32225 and our own RNA high-through sequencing three datasets; (C) The top 20 reliable enrichment items of overlapped DEGs sort by -log10(P); (D) Network of the top 20 items and the p value of these items, each node with different color is an enriched item, the size of the node represents the degree of enrichment. And the p-value are ranked by the shades of color.