Research Paper Volume 12, Issue 22 pp 22794—22813

Integrative analysis of transcriptomes highlights potential functions of transfer-RNA-derived small RNAs in experimental intracerebral hemorrhage

Figure 7. A model illustrating the study on the potential functions of tsRNAs after ICH. tsRNA is a novel class of short non-coding RNA cleaved from mature or precursor tRNA transcript. In a manner similar to miRNAs, tsRNAs containing some seed sequences might pair with the crosslink-centered regions of target mRNAs, leading to mRNA degradation. After ICH, the profile expression of tsRNAs is altered significantly. The subsequent effects on mRNA targets will lead to the changes of biological functions and to post-ICH pathophysiology.