Research Paper Volume 12, Issue 21 pp 21559—21581

Single-cell transcriptome analysis demonstrates inter-patient and intra-tumor heterogeneity in primary and metastatic lung adenocarcinoma

Figure 1. Schematic representation of the study strategy. Our study strategy included quality control, data integration and filtration of transcriptome data, cell clustering and identification of heterogeneous tumor cells from the same tumor samples, functional enrichment analysis, gene set variation analysis (GSVA), and tumor cell subgroup analysis.