Research Paper Volume 12, Issue 21 pp 21660—21673

Human mesenchymal stem cells treatment improved hepatic lesions and reversed gut microbiome disorder in non-alcoholic steatohepatitis

Figure 2. Human mesenchymal stem cells alleviated hepatic steatosis, inflammation, and fibrosis induced by MCD diet. (A) Representative images of HE-stained liver sections of the three groups. Steatosis, ballooning, and inflammation in the liver of the three groups were scored according to the NAFLD activity scoring system. (B) Representative images of Sirius Red-stained liver sections of the indicated groups. The fibrosis stages were evaluated according to the NAFLD activity score. (C) Relative mRNA levels of inflammatory cytokines (TNF-a and CXCL-2) and indicators of hepatic fibrosis (a-SMA and CTGF) from the MCD and MCD+hMSCs groups. * P < 0.05, ** P < 0.01, and *** P < 0.001.