Research Paper Volume 12, Issue 20 pp 20645—20657

Hsa_circ_0081534 increases the proliferation and invasion of nasopharyngeal carcinoma cells through regulating the miR-508-5p/FN1 axis


FN1 knockdown inhibited proliferative and invasive abilities of NPC cells. (A, B) FN1 expression levels in NPC tissues were analyzed through qRT-PCR and TCGA databases. (C) Relatively high levels of expression of FN1 were associated with poor prognosis for NPC patients. (D) The knockdown efficiency of si-FN1 in HONE1 cells. (E, F) Cell proliferative and invasive abilities post-knockdown of FN1 were determined through the use of colony formation and transwell assays. ESCA: esophageal carcinoma; HNSC: head and neck squamous cell carcinoma. *P < 0.05.