Research Paper Volume 12, Issue 21 pp 21674—21686

Circular RNA circSEMA5A promotes bladder cancer progression by upregulating ENO1 and SEMA5A expression

Figure 6. CircSEMA5A facilitates the glycolysis of BC cells via miR-330-5p/ENO1. (AF) T24 cells were transfected with circSEMA5A overexpression plasmids, miR-330-5p mimics and ENO1 overexpression plasmids; UM-UC-3 cells were transfected with circSEMA5A siRNAs, miR-330-5p inhibitors and ENO1 siRNAs. The level of ATP (A and B), relative glucose uptake (C and D) and lactate production (E and F) were subsequently measured. Data are presented as mean ± SD. *P < 0.05.