Research Paper Advance Articles pp 23795—23807

Demethoxycurcumin analogue DMC-BH exhibits potent anticancer effects on orthotopic glioblastomas

Figure 1. DMC-BH inhibited the viability of different glioma cells but had minor effects on normal (HEB) cells. (A) The chemical structures of DMC and DMC-BH. (BH) An MTT assay showed that DMC-BH inhibited the viabilities of SHG-44, C6, U251, U87, A172 and primary glioma cells in a dose- and time-dependent manner. (I) An MTT assay showed that treatment with DMC-BH had little toxic effect on normal (HEB) cells. The values are expressed as mean ± SEM (n = 3 per group).