Octanol-water partition coefficients (logP) and BBB penetrability of DMC-BH. (A) The logP was defined as log(Coctanol/Cwater). The amount of the compound in the water phase was determined spectrophotometrically, and the amount in the octanol phase was obtained by subtracting the supernatant concentration from the total concentration. (B) The BBB penetrability was defined as a brain-to-plasma AUC(time point) ratio. Values are expressed as the means ± SEM of 3 independent experiments.