Figure 3. DMC-BH inhibited U87 glioma cell growth in vivo. Subcutaneous tumors generated from U87 cells were allowed to reach a volume of 150-200 mm3 and were treated with 20 mg/kg TMZ, DMC or DMC-BH for 21 days. (A) Tumor volume was recorded according to treatment group at the indicated day. (B) The survival of brain tumor-bearing mice was recorded and represented in a Kaplan-Meier plot.