Research Paper Volume 12, Issue 21 pp 21854—21873

Three-gene risk model in papillary renal cell carcinoma: a robust likelihood-based survival analysis

Figure 8. The relationship between risk score and immune infiltration, TMB value. (A) The percentage of immune cell content in the various samples was showed, M2 macrophages accounted for the highest proportion. (B) The correlation between the proportion of immune cells in the samples and the risk score. M2 macrophages were positively related to risk score, while the M1 macrophages were negatively related to risk score. (C, D) The survival analysis to show M2-type macrophages account more proportion and lead a worse prognosis compared with M1-type macrophages. (E, F) Somatic mutations of TTN (P < 0.001) was higher both in low-risk group and high-risk group. (G) The patients with low risk score had higher TMB value, suggesting that the patients experienced better effects on the immune response and had a better prognosis.