Research Paper Volume 12, Issue 22 pp 22892—22905

USP10 deletion inhibits macrophage-derived foam cell formation and cellular-oxidized low density lipoprotein uptake by promoting the degradation of CD36

Figure 1. USP10 mediates lipid uptake by macrophage. Cells were treated with Spautin-1 for 24 h or USP10 siRNA for 48 h. Dil-oxLDL was added for the additional 6 h. DAPI for cell nucleus. The images were taken by confocal microscopy (A, C) and by flow cytometry (E, G). The fluorescence intensity was performed using Image pro plus (B, D) and quantitative analysis was showed (F, H). *p<0.05, **p<0.01, ***p<0.001 versus each vehicle control. DM:DMSO.